International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

Best Paper Award Selection - Editorial Board Site

2006, Volume8

Issue 1

98 pages

DOI: 10.1615/IntJMedMushr.v8.i1

Issue price - $138.00

Shafi Mojadadi
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran; and Department of Microbiology & Immunology, School of Medicine, Kerman Medical University, Kerman, Iran

Massoumeh Ebtekar
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran

Zuhair Mohammad Hassan
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran

Ganoderma lucidum has been recognized as an immunomodulatory natural product. This study investigated the effect of G. lucidum polysaccharide extract (Gl-PS) on the proliferation of mouse lymphocytes and the DTH (delayed type hypersensitivity) response test. Initially, we examined Gl-PS effect on proliferation of mouse lymphocytes in vitro, and then cell-mediated immune response was studied using the DTH test. Results indicate that Gl-PS 0.1 μg/ml can significantly increase proliferation of mouse lymphocytes in vitro. Finally, evaluation of the effect of Gl-PS on DTH response indicates that Gl-PS 100 mg/kg can increase DTH response against SRBC in BALB/c mice. We conclude that Gl-PS has a potent immunomodulatory effect and can be used for potentiation of the immune system against diseases, such as cancer, and other diseases in which the immune response has been weakened.

DOI: 10.1615/IntJMedMushr.v8.i1.70 Download article, 57-61 pages

Article price - $35.00

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