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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Screening and Isolation for Anti-hepatofibrotic Components from Medicinal Mushrooms using TGF-(β1−induced Live Fibrosis in Hepatic Stellate Cells

Volume 16, Issue 6, 2014, pp. 529-539
DOI: 10.1615/IntJMedMushrooms.v16.i6.30
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ABSTRACT

Liver fibrosis is a wound-healing response to chronic liver injury that could lead to liver failure, but treatment remains ineffective. In this study, we investigated anti-hepatic fibrosis activity of n-hexane, chloroform, ethyl acetate, and methanol extracts of mycelia from six commercially available medicinal mushrooms in submerged culture, namely Antrodia camphorata, Cephalosporium sinensis, Cordyceps mortierella, Hericium erinaceus, Ganoderma lucidum, and Armillaria mellea. Their anti-fibrotic activities were evaluated via inhibition against accumulation of TGF-β1−induced collagen deposition in CFSC-8B cells. Hex, Chl, and MeOH extracts of A. camphorata and Hex extract of A. mellea significantly decreased collagen production. Bioactivity-guided fractionation led to the identification of seven compounds using UPLC-Q-TOF-MS from the Hex Fr.2 of A. camphorata. At the molecular level, Hex Fr.2 of A. camphorata suppressed α-SMA, Collagen I, Collagen III, and Fibronectin expression induced by TGF-β1 in CFSC-8B cells as indicated by qRT-PCR analysis. They also inhibited α-SMA and Collagen I protein expression according to western blot analyses. Mechanistically, Hex Fr.2 of A. camphorata negatively regulates TGF-β1/Smad2/3 signaling. Our studies demonstrate that A. camphorata has in vitro anti-hepatofibrotic activity and that there is great potential for the discovery of new drugs for the treatment of liver fibrosis by screening more medicinal mushrooms.

CITED BY
  1. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  2. Tai Chen-Jei, Choong Chen-Yen, Lin Yu-Chun, Shi Yeu-Ching, Tai Cheng-Jeng, The anti-hepatic fibrosis activity of ergosterol depended on upregulation of PPARgamma in HSC-T6 cells, Food & Function, 7, 4, 2016. Crossref

  3. Wang Caicheng, Zhang Weiwei, Wong Jack Ho, Ng Tzibun, Ye Xiujuan, Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata, Applied Microbiology and Biotechnology, 103, 19, 2019. Crossref

  4. Zhang Ai Hua, Jiang Nan, Wang Xing Qi, Tan Ren Xiang, Galewone, an Anti-Fibrotic Polyketide from Daldinia eschscholzii with an Undescribed Carbon Skeleton, Scientific Reports, 9, 1, 2019. Crossref

  5. Gallego Paloma, Luque-Sierra Amparo, Falcon Gonzalo, Carbonero Pilar, Grande Lourdes, Bautista Juan D., Martín Franz, Del Campo José A., White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice, Foods, 10, 8, 2021. Crossref

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