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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Inhibits Proliferation of Human Peripheral Blood Lymphocytes by Blocking lnterleukin-2 Secretion

Volume 2, Issue 4, 2000, 9 pages
DOI: 10.1615/IntJMedMushr.v2.i4.110
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ABSTRACT

Ganoderma lucidum is a famous medicinal mushroom that has various immunomodulating activities such as inhibition of antibody production, immunosuppressive antiviral activity, and inhibition of histamine release. However, there are few reports on the direct immunomodulating effects of this mushroom on human peripheral blood immunocompetent cells. For elucidation of the immunosuppressive mechanism of this mushroom, a methanolic (GLA) extract of its basidiocarps was fractionated into six parts. When each of the six fractions was applied to the adherent and nonadherent cells of human peripheral blood mononuclear cells (PBMCs), proliferative arrest was observed and growth arrest was stronger in the nonadherent cells than in the adherent cells. As the chloroform fraction of the fungus (GLE) arrested most strongly, it was further purified by silica gel column chromatography into seven subfractions. Among them, GLE1 fraction, the highest Rf value fraction, inhibited cell proliferation in a concentration-dependent manner. Antiproliferative activity of the GLE1 fraction was also observed in human allogeneic mixed lymphocyte culture (MLC). When secreted interleukin-2 (IL-2) of the culture supernatant of the MLC was measured by enzyme-linked immunosorbent assay (ELISA), the GLE1 fraction was found to inhibit IL-2 secretion, which was comparable to the effect of the immunosuppresive agent cyclosporin A. These data indicate that antiproliferating activity of the GLE1 fraction blocked IL-2 secretion. The GLE1 fraction of G. lucidum therefore may have the potential to be developed into an immunomodulating agent.

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