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International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

Institutional price:	$538.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2007, Volume9

96 pages

DOI: 10.1615/IntJMedMushr.v9.i1

Issue price - $149.00

Adverse Effects of Mycelia and Culture Broth Extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on Breast and Prostate Cancer Cells

Ben-Zion Zaidman
Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel; and Migal, Galilee Technology Center, Cancer Drug Discovery Program, P.O. Box 831, Kiryat Shmona 11016, Israel

Anna Lutin
Migal, Galilee Technology Center, Cancer Drug Discovery Program, P.O. Box 831, Kiryat Shmona 11016, Israel

Solomon P. Wasser
International Centre for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, Israel; and N.G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Kiev, Ukraine

Eviatar Nevo
Institute of Evolution, and Department of Evolutionary and Environmental Biology, Faculty of Science and Science Education, University of Haifa, Mt. Carmel, Haifa, 31905 Israel

Jamal A. Mahajna
Migal, Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona; Galilee Institute for Applied Research, Nazareth, Israel

ABSTRACT

Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.