International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume6

Issue 3

110 pages

DOI: 10.1615/IntJMedMushr.v6.i3

Issue price - $128.00

Christopher Hobbs
Institute for Natural Products Research, Davis, CA 95065; and Institute for Natural Products Research, 4731 East Fork Rd., Williams, OR 97544, USA

Trametes (=Coriolus) versicolor (L.:Fr.) Pilát, is a small, flexible polypore fungus that is an important part of the forest ecology as a recycler of dead and dying trees in forests throughout the world. Of all the mushrooms used today for their medicinal qualities, more research has been performed on this species than any other, including shiitake (Lentinus edodes), or reishi (Ganoderma lucidum).High-molecular-weight fractions from the mycelium have been studied in human clinical trials, especially polysaccharide Krestin (PSK), which is an approved drug paid for by national health care in Japan. PSK is given orally (often 3 grams/day), along with several chemotherapy protocols. Numerous in vitro and in vivo studies show enhancement of immune functions, antiviral effects, and cholesterol-regulating effects, among others. New clinical trials demonstrate improved quality of life after surgery and in combination with chemotherapy, as well as extended 5- and 10-year survival rates, especially for patients with colorectal and stomach cancers. Further studies are needed in order to clarify the most effective forms of the whole fruiting body extracts, mycelium extracts, and their high-molecular weight fractions, along with the optimum dose. Safety issues, while not completely determined for long-term treatment, during pregnancy, or in combination with pharmaceutical drugs, seem to be of low concern, with no noted published side effects or interactions with drugs reported.

DOI: 10.1615/IntJMedMushr.v6.i3.10 Download article, 24 pages

Article price - $35.00

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