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International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

Institutional price:	$538.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2006, Volume8

109 pages

DOI: 10.1615/IntJMedMushr.v8.i2

Issue price - $138.00

Effects of Polysaccharides Isolated from Agaricus brasiliensis (Agaricomycetideae) on Splenic Hematopoiesis in Mice

Yoshiaki Fujimiya
Division of Biotechnology, Sumitomo Forestry Tsukuba Research Institute, 3-2, Midorigahara, Tsukuba; and Department of Microbiology and Immunology, Hachinohe University School of Human Health Sciences, Hachinohe, Aomori 031-8566, Japan

Debra S. Groveman
Veterans Administration Hospital, White River Junction, VT 05009

Yoshihiro Takei
INA Research, K.K. Ina, Nagano 399-4501, Japan

Youichi Suzuki
Suzuki Neurosurgery Medical Center, Watari, Miyagi, 989-2301, Japan

Masahide Noji
Department of Clinical Nutrition, Suzuka University of Medical Science, Kishioka-cho, Suzuka, Japan

ABSTRACT

The administration of ethanol-soluble, boiling water-soluble, and ammonium oxalate-insoluble fractions (essentially β-1, 6-D glucose) isolated from the fruiting bodies of Agaricus brasiliensis into C3H/HeN mice resulted in a marked proliferation of cells of multicell lineages in the splenic compartment. Phenotypically increased expression of NK1.1⁺ on lymphoid cells and histologically increased proliferations of megakaryocytic progenitor cells were seen in the splenic compartment. These results indicate that β-1, 6-D polysaccharides may play a critical role in the maintenance of hematopoietic cells for compromised patients at the risk of infection associated with malignancy.