International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

Best Paper Award Selection - Editorial Board Site

2002, Volume4

Issue 1

80 pages

Issue price - $128.00

Mitsuaki Sano
Laboratory of Health Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526, Japan

Kyoji Yoshino
Department of Biochemistry, Numazu College of Technology, 3600 Ooka, Numazu-shi, Shizuoka 410-8501, Japan

Tsunetomo Matsuzawa
Agricultural Technology Institute of Nagano Farmers Federation 787-1 Suzaka, Suzaka-shi, Nagano 382-0084, Japan

Tetsuro Ikekawa
Japanese Association of Integrative Medicine (JAIM). Association for Popularization of Integrative Medicine and Treatments (NPO, Japan), Sanshin Building, 3F, 2-15-14 Uchikanda, Chiyoda-ku, Tokyo 101-0047,Japan

The inhibitory effects of edible higher Basidiomycetes mushroom extracts from Hypsizygus marmoreus (Peck) Bigel.., Flammulina velutipes (Curt.: Fr.)P. Karst., Pholiota nameko (T. Ito) S. Ito et Imai, and Pleurotus eryngii (DC.: Fr.) Quel. on oxazolone-induced type IV allergy in male ICR mice were investigated. Oral administration of the ethanol extracts of these mushroom species for 3 days before the challenge showed significant antiallergic effects at a dose of 250 mg/kg bw/day. However, oral administration of the extracts for 3 days before the sensitization had no antiallergic effect at the same dose. A single percutaneous administration of the mushroom extracts together with the challenge also resulted in significant antiallergic effects at a dose of 0.1 mg/ear. The, results suggest that ethanol extracts of these mushroom species suppress the hypersensitive immune response such as the inflammation in delayed allergy.

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