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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide−Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes

Volume 17, Issue 11, 2015, pp. 1069-1076
DOI: 10.1615/IntJMedMushrooms.v17.i11.70
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ABSTRACT

We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)−induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC50s) of IO-W for radical-scavenging activity against 2,2'-azino-bis-(3-ethylbenzothi- azoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) were 5.19 mg/mL and 0.39 mg/mL, respectively. IO-W pretreatment to the primary cultured hepatocytes significantly (p<0.05) protected the cells from t-BHP-induced cytotoxic injury even at a low concentration of IO-W (10 µg/mL). The cellular leakage of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), as well as malondialdehyde (MDA) formation caused by t-BHP were significantly (p<0.05) suppressed by IO-W pretreatment (>100 µg/ mL). In conclusion, this study demonstrates that IO-W exhibited hepatoprotective activity against t-BHP−induced oxidative liver injury in the primary cultured hepatocyte probably via its abilities of quenching free radicals, inhibiting the leakage of ALT, AST, and LDH, and decreasing MDA formation.

CITED BY
  1. Jayachandran Muthukumaran, Xiao Jianbo, Xu Baojun, A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota, International Journal of Molecular Sciences, 18, 9, 2017. Crossref

  2. Meng Xiao, Li Ya, Li Sha, Gan Ren-You, Li Hua-Bin, Natural Products for Prevention and Treatment of Chemical-Induced Liver Injuries, Comprehensive Reviews in Food Science and Food Safety, 17, 2, 2018. Crossref

  3. Zhao Yanxia, Zheng Weifa, Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus, Journal of Ethnopharmacology, 265, 2021. Crossref

  4. Ishfaq Pir Mohammad, Mishra Shivani, Mishra Anjali, Ahmad Zaved, Gayen Shovanlal, Jain Subodh Kumar, Tripathi Swati, Mishra Siddhartha Kumar, Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin, Current Research in Pharmacology and Drug Discovery, 3, 2022. Crossref

  5. Ishfaq Pir Mohammad, Mishra Anjali, Mishra Shivani, Ahmad Zaved, Gayen Shovanlal, Jain Subodh Kumar, Tripathi Swati, Mishra Siddhartha Kumar, Inonotus obliquus Aqueous Extract Suppresses Carbon Tetrachloride-induced Hepatic Injury through Modulation of Antioxidant Enzyme System and Anti-inflammatory Mechanism, Clinical Cancer Drugs, 8, 2, 2021. Crossref

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