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International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

Institutional price:	$538.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2008, Volume10

104 pages

DOI: 10.1615/IntJMedMushr.v10.i1

Issue price - $161.00

In Vitro Anti-inflammatory Activity of Selected Japanese Higher Basidiomycetes Mushrooms

Esameldin E. Elgorashi
Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, 4-101 Minami, Koyama, Tottori 680-8553, Japan

Nitaro Maekawa
The Tottori Mycological Institute, Kokoge 211, Tottori-shi, Tottori 689-1125, Japan

Hiroshi Satoh
Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, 4-101 Minami, Koyama, Tottori 680-8553, Japan

ABSTRACT

Mycelial extracts (ethyl acetate and 70% ethanol) of 20 higher Basidiomycetes edible or medicinal mushrooms and culture media extracts (ethyl acetate and Butan-1-ol) were evaluated for in vitro anti-inflammatory activity using the cyclooxygenase-1 and -2 enzymes (COX-1 and -2). Generally, 70% ethanolic extracts showed lower inhibitory activity against both enzymes compared to ethyl acetate extracts. Of the mushrooms tested, the ethyl acetate extracts of Ganoderma applanata, Naematoloma sublateritium, Pleurotus eryngii, and P. salmoneostramineus showed the highest COX-2 inhibitory effects (IC₅₀ values of 49.7, 80.6, 121.7, and 115.8 μg/mL, respectively) compared to COX-1 inhibition (IC₅₀ values of 125.3, 156, 188.9, and 250 μg/mL, respectively). Of the culture media tested in this study, only the ethyl acetate extracts of the culture medium of Agrocybe cylindracea exhibited high inhibition of the COX-2 enzyme.