International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

Best Paper Award Selection - Editorial Board Site

2000, Volume2

Issue 3

88 pages

Issue price - $128.00

Susan Jones
Amala Cancer Research Centre, Amala Nagar, Trichur-680553, India

Kainoor K. Jananrdhanan
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

Antioxidant and antitumor properties of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) from tropical South India were investigated. A methanol extract of the mushroom showed marked superoxide radical scavenging, hydroxyl radical scavenging, and lipid peroxidation inhibiting activities. The superoxide scavenging activity of the extract was significantly high. The aqueous extract also showed marked hydroxyl radical scavenging and superoxide radical scavenging activity. Hydroxyl radical scavenging activity of the extract was significantly high. However, the aqueous extract did not inhibit lipid peroxidation. Neither methanol nor aqueous extract showed any appreciable antitumor activity against ascites tumor. However, the extracts exhibited significant antitumor activity against solid tumor induced by Ehrlich's ascites carcinoma cells. The results of the investigations indicate that G. lucidum strains occurring in tropical South India possessed significant antioxidant and antitumor properties. The findings suggest the potent therapeutic use of South Indian strains of G. lucidum.

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