International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

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2003, Volume5

Issue 1

102 pages

DOI: 10.1615/InterJMedicMush.v5.i1

Issue price - $128.00

Stefan Bender
Environment and Biotechnology Centre,Swinburne University of Technology, John Str.,Hawthorn,Melbourne,Australia; Fachhochschule Institute for IInstrumental Analysis,Mannheim; Merck KgaA, Preclinical R&D, Medicinal Chemistry LF, 64271 Darmstadt,Germany

Cristina N. Dumitrache-Anghel
Environment and Biotechnology Centrer,Centre for Applied Colloid and BioColloid Science, Swinburne University of Technology, John Street, Hawthorn, Melbourne, Australia; Present address: Novo Nordisk A/S, Novo Alle, DK-2800, Bagsvaerd, Copenhagen, Denmark

Juergen Backhaus
Fachhochschule Mannheim, Institute for Instrumental Analysis, Mannheim University of Applied Sciences, Germany

Gregor Christie
Environment and Biotechnology Centre, Swinburne University of Technology, John Street, Hawthorn, Melbourne 3122, Australia

Reg F. Cross
Centre for Applied Colloid and BioColloid Science, School of Engineering and Science, Swinburne University of Technology, John Street, Hawthorn, Melbourne 3122, Australia

Greg T. Lonergan
Environment and Biotechnology Centre; Centre for Applied Colloid and BioColloid Science, School of Engineering and Science, Swinburne University of Technology, John Street, Hawthorn, Melbourne 3122, Australia

Warren L. Baker
Environment and Biotechnology Centre, Centre for Applied Colloid and BioColloid Science, School of Engineering and Science, Swinburne University of Technology, John Street, Hawthorn, Melbourne 3122, Australia

Antimicrobial activity against Staphylococcus aureus was detected when edible and medicinal mushroom Lentinus edodes was grown in malt extract broth. The broth was subjected to anion-exchange chromatography. A solution of the dried eluate from the anion-exchange column showed a peak in the same position as pure oxalic aid when subjected to ion-pair chromatography. Treatment of pure oxalic acid and the dried eluate with diazomethane, followed by gas chromatography and mass spectrometry, gave several peaks, but a peak at retention time 4.8 min showed all the characteristics of dimethyl oxalate. It was concluded that oxalic acid was one agent responsible for the antimicrobial effect and oxalic acid was shown to exert such an effect against several other organisms.

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