Alex
Moroz, M.D. Alex
Leali, M.D. Mathew
Lee, M.D., M.P.H. Angela
Liu ABSTRACT Reflex sympathetic dystrophy (chronic regional pain syndrome [CRPS], type 1) is a syndrome that usually develops after an initiating noxious event, is not limited to the distribution of a single peripheral nerve, and is apparently disproportionate to the inciting event. It is associated at some point with evidence of edema, changes in skin blood flow, abnormal sudomotor activity in the region of the pain, or allodynia or hyperalgesia. Following a historical review as it relates to evolving theories of etiology and pathogenesis of CRPS, this article reviews evidencebased knowledge that is currently available regarding demographics, diagnosis, treatment, and outcomes after CRPS.
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