Critical Reviews™ in Neurobiology

ISSN for PRINT: 0892-0915

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume16

Issue 3

42 pages

DOI: 10.1615/CritRevNeurobiol.v16.i3

Issue price - $126.00

Kevin Erreger
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA

Philip E. Chen
Division of Neuroscience, University of Edinburgh, Edinburgh, UK

David J. A. Wyllie
Division of Neuroscience, University of Edinburgh, Edinburgh, UK

Stephen F. Traynelis, PhD
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA

Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic transmissions within the mammalian central nervous system (CNS). As for other ion channel protein families, there has been astounding progress in recent years in elucidating the details of protein structure through the crystallization of at least part of the ion channel protein complex. The result is a new framework for the interpretation of both classic and emerging functional data. Here we summarize, compare, and contrast recent findings for the AMPA, kainate, and NMDA subtypes of glutamate receptor ion channels, with an emphasis on the functional and structural aspects of how agonist binding controls channel gating.

DOI: 10.1615/CritRevNeurobiol.v16.i3.10 Download article, 187-224 pages

Article price - $250.00