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Critical Reviews™ in Neurobiology

ISSN for PRINT: 0892-0915

Institutional price:	$649.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2006, Volume18

209 pages

Issue price - $338.00

Translational Control of Long-Term Synaptic Plasticity and Memory Storage by eIF2α

Mauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Centre, Montreal, Québec, Canada

Nahum Sonenberg
Department of Biochemistry and McGill Cancer Centre, Montreal, Québec, Canada

ABSTRACT

Both long-lasting changes in synaptic function and long-term memory require gene expression. However, the molecular mechanisms by which gene expression is turned on are not fully understood. In this review, we highlight the role of the eukaryotic initiation factor 2 α (eIF2α) signalling pathway in long-term synaptic plasticity and memory.