Critical Reviews™ in Neurobiology

ISSN for PRINT: 0892-0915

For Online Access

Best Paper Award Selection - Editorial Board Site

2006, Volume18

Issue 1-2

209 pages

Issue price - $338.00

Zhong-wei Zhang
The Jackson Laboratory, Bar Harbor, ME

The sensory relay synapses in the thalamus undergo extensive refinement during early life. Disruptions of spontaneous activity, but not sensory deprivation, can induce large-scale re-organization of neuronal connections in the thalamus. Recent studies also reveal an extended period of synaptic refinement in the visual and somatosensory relay synapses, where sensory deprivation produces some unexpected effects on synaptic remodeling. This article aims to provide a brief overview of recent findings and current ideas about the refinement of relay synapses in the thalamus.

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