Critical Reviews™ in Neurobiology

ISSN for PRINT: 0892-0915

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume16

Issue 1&2

194 pages

DOI: 10.1615/CritRevNeurobiol.v16.i12

Issue price - $252.00

Britt Mellstrom
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain

Begona Torres
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain

Wolfgang A. Link
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain

Jose R. Naranjo
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain

Over the last 20 years, great effort has been made to decipher the molecular mechanisms used by cells to transform a cytosolic Ca²⁺ signal into specific, finely-controlled changes in gene expression. Several previous reviews addressed the variety of regulatory mechanisms that participate in Ca²⁺-dependent gene expression in neurons (Carafoli et al., 2001; Mellström and Naranjo 2001; West et al., 2001). Nevertheless, recent discoveries have revealed new players and new interactions that tune this process. In this review, we will use the four promoters that regulate the expression of the brain-derived neurotrophic factor (BDNF) gene as a magnificent scenario in which these mechanisms intermingle to show the complexity of Ca²⁺-dependent gene expression.

DOI: 10.1615/CritRevNeurobiol.v16.i12.40 Download article, 43-50 pages

Article price - $35.00

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