Critical Reviews™ in Neurobiology

ISSN for PRINT: 0892-0915

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume16

Issue 4

82 pages

DOI: 10.1615/CritRevNeurobiol.v16.i4

Issue price - $126.00

Wei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, USA; and Department of Neurology, First Clinical Hospital, Dalian, China

Jau-Shyong Hong
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA

Hyoung-Chun Kim
College of Pharmacy, Kangwon National University, Chunchon, Korea

Wanqin Zhang
Department of Physiology, Dalian Medical University, Dalian, China

Michelle L. Block
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA

Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinson’s disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure. The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed.

DOI: 10.1615/CritRevNeurobiol.v16.i4.30 Download article, 271-302 pages

Article price - $50.00

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