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Critical Reviews™ in Eukaryotic Gene Expression

Impact Factor: 2.385
5-Year Impact Factor: 3.082

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Volume 25, 2015

Volume 24, 2014

Volume 23, 2013

Volume 22, 2012

Volume 21, 2011

Volume 20, 2010

Volume 19, 2009

Volume 18, 2008

Volume 17, 2007

Volume 16, 2006

Volume 15, 2005

Volume 14, 2004

Volume 13, 2003

Volume 12, 2002

Volume 11, 2001

Volume 10, 2000

Volume 9, 1999

Volume 8, 1998

Volume 7, 1997

Volume 6, 1996

Volume 5, 1995

Volume 4, 1994

Issue 1

Issue 2-3

Critical Reviews™ in Eukaryotic Gene Expression

Executive Editors: Gary Stein , Janet L. Stein , Jane B. Lian

Managing Editor: Nicholas Thompson

Aims and Scope

Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered. The contributions of molecular, cellular, biochemical, genetic, genomic, and proteomic approaches to eukaryotic gene expression are incorporated into reviews. The relationship between gene structure and function is stressed, with emphasis on coordinate control of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence structure and expression of eukaryotic genes as well as in relation to cellular architecture and its relationship to development of cell specialization and tissue organization. Processes that include genetic and epigenetic control, cell cycle regulation, differentiation, transformation and tumorigenesis, senescence, cell survival and apoptosis, development, reproduction, cell fate, lineage commitment, stem cell biology and regenerative medicine are covered.
All articles are by invitation; however, the editors welcome suggestions of both topics and authors.

Most Downloaded Articles

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases
Julio Morales, Longshan Li, Farjana J. Fattah, Ying Dong, Erik A. Bey, Malina Patel, Jinming Gao, David A. Boothman

Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
Yingwei Chen , Wen Jie, Weihui Yan, Kejun Zhou, Yongtao Xiao

The Different Molecular Mechanisms of Mitophagy Between Yeast and Mammals
Ying Song, Yan Xiao, Jia-Ming Wang, Qi Chen

HITS-CLIP and PAR-CLIP Advance Viral MiRNA Targetome Analysis
Irina Haecker, Rolf Renne

The Roles of Bacterial GCN5-Related N-acetyltransferases
Longxiang Xie, Jie Zeng, Hongping Luo, Weihua Pan, Jianping Xie

Bi-Directional Signaling: Extracellular Matrix and Integrin Regulation of Breast Tumor Progression
Scott Gehler, Suzanne M. Ponik, Kristin M Riching, Patricia J. Keely