Critical Reviews™ in Eukaryotic Gene Expression
Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered. The contributions of molecular, cellular, biochemical, genetic, genomic, and proteomic approaches to eukaryotic gene expression are incorporated into reviews. The relationship between gene structure and function is stressed, with emphasis on coordinate control of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence structure and expression of eukaryotic genes as well as in relation to cellular architecture and its relationship to development of cell specialization and tissue organization. Processes that include genetic and epigenetic control, cell cycle regulation, differentiation, transformation and tumorigenesis, senescence, cell survival and apoptosis, development, reproduction, cell fate, lineage commitment, stem cell biology and regenerative medicine are covered.
All articles are by invitation; however, the editors welcome suggestions of both topics and authors.
Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Loreana Sanches Silveira, Barbara de Moura Mello Antunes, Andre Luis Araujo Minari, Ronaldo Vagner Thomatieli dos Santos, José Cesar Rosa Neto, Fábio Santos Lira
Bone Modeling and Remodeling
mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management
Silvia Cetrullo, Stefania D'Adamo, Benedetta Tantini, Rosa Maria Borzi , Flavio Flamigni
Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
Yingwei Chen , Wen Jie, Weihui Yan, Kejun Zhou, Yongtao Xiao
Clinical Genomics: Challenges and Opportunities
Priyanka Vijay, Alexa B. R. McIntyre, Christopher E. Mason, Jeffrey P. Greenfield, Sheng Li
Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia
Alexandre Abilio de Souza Teixeira, Fábio Santos Lira, Gustavo D Pimentel, Camila Oliveira de Souza, Helena Batatinha, Luana A Biondo, Alex S Yamashita, Edson A Lima Junior, José Cesar Rosa Neto