Critical Reviews™ in Immunology
The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.
The articles that appear in CRI are usually obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested parties should send their inquiries to the Editor before submitting a manuscript.
Reviewed Articles: The journal publishes critical and timely review articles in various aspects of contemporary immunology. These review articles constitute the major part of any given issue. It is hoped that the articles will provide a critical analysis rather than a passive account of information in a given topic. The articles are rigorously refereed by outstanding and expert investigators. Review articles are, therefore, by invitation and unsolicited papers cannot be considered. However, proposals for reviews are encouraged and will be seriously considered by the Editorial Board. A proposal should give a short description (about one page) of the intended work.
The phenomenal advances in the field of immunology make it a dynamic and continuously changing field. With such an explosion of knowledge and information, concepts and dogmas often lag behind and might even become outdated. To allow constructive discussion among immunologists and to maximize exchange of ideas the journal will publish (in addition to the review articles) the following:
Opinions/hypotheses: These are proposed concepts, based on sound experimental data that should be available in the scientific literature. The hypothesis, which does not have to be based on the author's own experimental work, should outline consequences that could be tested by experiments. Opinions and hypotheses are subject to the usual peer review process.
Letters to the Editor: These could be responses to hypotheses, clarifications, viewpoints, and other such matters that will encourage discussion. This is an open forum. The letters, however, should be scholarly, and personal attacks or abusive style will not be permitted. Letters to the editor will be peer reviewed.
News and Comments: These include important news items such as major breakthroughs and new discoveries in immunology and even other biological sciences that might have an impact on the field of immunology. Summaries of national and international meetings are also appropriate news items.
Book Reviews and Books Received: Authors and publishers of immunology books are invited to submit their books for review and evaluation by the journal. Usually, one or two reviews can be assigned to a given issue. However, as a service to the scientific community, all books that are received will be listed.
Calendar of Events: As a service to the scientific community, the journal will list titles and dates of immunology meeting up to one year in advance. Organizers of future meetings are encouraged to submit title, date, location, and name/address/telephone number of the person to contact for further information. There will be no charge for this service.
LPS-induced Cytokine Production in Human Monocytes and Macrophages
Manuela Rossol, Holger Heine, Undine Meusch, Dagmar Quandt, Carina Klein, Matthew J. Sweet, Sunna Hauschildt
M1 and M2 Macrophages: Oracles of Health and Disease
Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression
Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Yoshio Hayashi, Naozumi Ishimaru
Pathogenesis of Multiple Organ Failure in Sepsis
Jan Rossaint , Alexander Zarbock
The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells
Adriana Alicia Cabrera-Ortega, Daniel Feinberg, Youde Liang, Carlos Rossa, Jr., Dana T. Graves
Immune Functions of Serum Amyloid A
Kari K. Eklund, K. Niemi, P. T. Kovanen