In this paper on the basis of the classical bubble dynamics, the authors bring forward a new model for the bubble growth in a nucleation boiling system-the comprehensive interface model. The essence of the model is that the thermodynamic analysis for the status variation in a bubble is put into the first consideration. The heat and mass transfer on the interface of the bubble are considered in detail, especially in the circumstances of the boiling explosion. And some simulated calculations are carried out and the results are compared with experimental data. This model reveals the pressure and temperature variation in the process of bubble growing first time and provides a reasonable solution to numerically simulate the bubble growth or the development of vapor film. The temperature variation of the heating surface and the properties of the liquid govern the time length of the early bubble growing stage.