Critical ReviewsTM in Eukaryotic Gene Expression (CRE) publishes original research findings and critical reviews that contribute to advances in mechanistic understanding for genetic and epigenetic control of gene expression, organization and structure within the contexts of biological control and the diagnosis/treatment of disease. Contributions include molecular, cellular, biochemical, genetic, genomic, proteomic and bioinformatic approaches to eukaryotic gene expression. The relationship between gene structure and function is stressed, with emphasis on coordinate control of integration of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence organization and expression of eukaryotic genes as well as in relation to cellular architecture and development of cell specialization and tissue organization. Processes that include genetic and epigenetic control, cell cycle regulation, differentiation, transformation and tumorigenesis, senescence, cell survival and apoptosis, development, reproduction, cell fate, lineage commitment, stem cell biology and regenerative medicine as well as molecular epidemiology are covered.